Notes
Functional activity
All neoplasms are classified in this chapter, whether they are functionally active or not. An additional code from Chapter 4 may be used, to identify functional activity associated with any neoplasm.
Morphology [Histology]
Chapter 2 classifies neoplasms primarily by site (topography), with broad groupings for behavior, malignant, in situ, benign, etc. The Table of Neoplasms should be used to identify the correct topography code. In a few cases, such as for malignant melanoma and certain neuroendocrine tumors, the morphology (histologic type) is included in the category and codes.
Primary malignant neoplasms overlapping site boundaries
A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned.
Malignant neoplasm of ectopic tissue
Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified (C25.9).
Codes
C00-C14
Malignant neoplasms of lip, oral cavity and pharynx
C15-C26
Malignant neoplasms of digestive organs
C30-C39
Malignant neoplasms of respiratory and intrathoracic organs
C40-C41
Malignant neoplasms of bone and articular cartilage
C43-C44
Melanoma and other malignant neoplasms of skin
C45-C49
Malignant neoplasms of mesothelial and soft tissue
C50-C50
Malignant neoplasms of breast
C51-C58
Malignant neoplasms of female genital organs
C60-C63
Malignant neoplasms of male genital organs
C64-C68
Malignant neoplasms of urinary tract
C69-C72
Malignant neoplasms of eye, brain and other parts of central nervous system
C73-C75
Malignant neoplasms of thyroid and other endocrine glands
C7A-C7A
Malignant neuroendocrine tumors
C7B-C7B
Secondary neuroendocrine tumors
C76-C80
Malignant neoplasms of ill-defined, other secondary and unspecified sites
C81-C96
Malignant neoplasms of lymphoid, hematopoietic and related tissue
D00-D09
In situ neoplasms
D10-D36
Benign neoplasms, except benign neuroendocrine tumors
D3A-D3A
Benign neuroendocrine tumors
D37-D48
Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes
D49-D49
Neoplasms of unspecified behavior
Versions
2025
No changes
2024
No changes
2023
No changes
2022
No changes
2021
No changes
2020
No changes
2019
No changes
2018
No changes
2017
No changes
2016
New code