2025
ICD-10-CM
Diagnosis
Code

R65.2 Severe sepsis

  • Non-billable
  • 2016–2025

R65.2 is a non-billable/non-specific diagnosis code from the 2025 ICD-10-CM used to classify the following condition: Severe sepsis.

Inclusion term

  • Infection with associated acute organ dysfunction

  • Sepsis with acute organ dysfunction

  • Sepsis with multiple organ dysfunction

  • Systemic inflammatory response syndrome due to infectious process with acute organ dysfunction

Code first

  • Underlying infection, such as:

    • Infection following a procedure (T81.4-)

    • Infections following infusion, transfusion and therapeutic injection (T80.2-)

    • Puerperal sepsis (O85)

    • Sepsis following complete or unspecified spontaneous abortion (O03.87)

    • Sepsis following ectopic and molar pregnancy (O08.82)

    • Sepsis following incomplete spontaneous abortion (O03.37)

    • Sepsis following (induced) termination of pregnancy (O04.87)

    • Sepsis NOS (A41.9)

Use additional code

  • Code to identify specific acute organ dysfunction, such as:

    • Acute kidney failure (N17.-)

    • Acute respiratory failure (J96.0-)

    • Critical illness myopathy (G72.81)

    • Critical illness polyneuropathy (G62.81)

    • Disseminated intravascular coagulopathy [DIC] (D65)

    • Encephalopathy (metabolic) (septic) (G93.41)

    • Hepatic failure (K72.0-)

Codes

Versions

  1. 2025

    No changes

  2. 2024

    No changes

  3. 2023

    No changes

  4. 2022

    No changes

  5. 2021

    No changes

  6. 2020

    No changes

  7. 2019

    No changes

  8. 2018

    No changes

  9. 2017

    Code changed

    • Code first

        • underlying infection, such as:
        • infection following a procedure (T81.4)
        • infections following infusion, transfusion and therapeutic injection (T80.2-)
        • puerperal sepsis (O85)
        • sepsis following complete or unspecified spontaneous abortion (O03.87)
        • sepsis following ectopic and molar pregnancy (O08.82)
        • sepsis following incomplete spontaneous abortion (O03.37)
        • sepsis following (induced) termination of pregnancy (O04.87)
        • sepsis NOS (A41.9)
        • underlying infection, such as:
        • infection following a procedure (T81.4-)
        • infections following infusion, transfusion and therapeutic injection (T80.2-)
        • puerperal sepsis (O85)
        • sepsis following complete or unspecified spontaneous abortion (O03.87)
        • sepsis following ectopic and molar pregnancy (O08.82)
        • sepsis following incomplete spontaneous abortion (O03.37)
        • sepsis following (induced) termination of pregnancy (O04.87)
        • sepsis NOS (A41.9)

  10. 2016

    New code