2025
ICD-10-CM
Diagnosis
Code

M35.81 Multisystem inflammatory syndrome

  • Billable
  • 2021–2025

M35.81 is a billable/specific diagnosis code from the 2025 ICD-10-CM used to classify the following condition: Multisystem inflammatory syndrome.

Inclusion term

  • MIS-A

  • MIS-C

  • Multisystem inflammatory syndrome in adults

  • Multisystem inflammatory syndrome in children

  • Pediatric inflammatory multisystem syndrome

  • PIMS

Code first

  • If applicable, COVID-19 (U07.1)

Code also

  • Any associated complications such as:

    • Acute hepatic failure (K72.0-)

    • Acute kidney failure (N17.-)

    • Acute myocarditis (I40.-)

    • Acute respiratory distress syndrome (J80)

    • Cardiac arrhythmia (I47-I49.-)

    • Pneumonia due to COVID-19 (J12.82)

    • Severe sepsis (R65.2-)

    • Viral cardiomyopathy (B33.24)

    • Viral pericarditis (B33.23)

Use additional code

  • Code, if applicable, for:

    • Exposure to COVID-19 or SARS-CoV-2 infection (Z20.822)

    • Personal history of COVID-19 (Z86.16)

    • Post COVID-19 condition (U09.9)

Versions

  1. 2025

    No changes

  2. 2024

    No changes

  3. 2023

    No changes

  4. 2022

    Code changed

    • Use additional code

        • code, if applicable, for:
        • exposure to COVID-19 or SARS-CoV-2 infection (Z20.822)
        • personal history of COVID-19 (Z86.16)
        • sequelae of COVID-19 (B94.8)
        • code, if applicable, for:
        • exposure to COVID-19 or SARS-CoV-2 infection (Z20.822)
        • personal history of COVID-19 (Z86.16)
        • post COVID-19 condition (U09.9)

  5. 2021

    New code